I’ve been using Blender versions up to 2.26 with no problems (Win 98 SE, Athlon XP2000+, ATI Radeon 7500). I tried 2.27 when it was released and it locked the machine up. V2.28 did the same. I’ve tried removing older versions from the system but it made no difference. Has anyone else had this problem?
If you have reason to suspect that another version is causing the problem then delete .B.blend file in C:\Documents and Settings\user\Application Data\Not a Number\Blender. In fact you can delete all the files in that folder. Then fire up 2.28 and it will create its own default files.
You can also try disabling international fonts in 2.28, though I don’t know how you would do this if it’s locked up.
If it’s not there look at z3ro_d’s sticky thread at the top of this page.