The posts in this thread are a great reminder that it’s always a great idea to have more than one app in your toolkit for getting a certain kind of thing done.
Ideally, you can “stay in the tool” 100% of the time, but what if that software simply can’t do one particular bit?
I have used Inkscape for real work and I found it to be worthy, but I’ve also experienced the snarkyness PhysicsGuy described and I think lately, for me, it is because OS X support is lagging behind that for Linux and Win…I’m a Mac user.
Blender continues to impress me for, open source or not, the devs exemplify how a software application can grow and mature and evolve into something amazing and effective and that it need not become a blubber-packed bugfest as some, er, commercial titles have been known to do.
I have CS6 loaded on my machine, but my main tools are: Pixelmator, Sketch 3, LibreOffice, and Blender, for creating and manipulating…text, design, imagery. These don’t replace CS6 in the app for app sense, but between these 4 I can get done what I need to do without being trapped into paying a monthly fee.