I’m surprised I haven’t seen this done before. If it has, please forgive me. 
Anyway, I’m making this topic to talk about what’s important in a CG program’s interface, and what features are important to have access to in your immediate Blender window. You can share our custom Blender GUIs if you want, too.
I just thought it’d be cool to get some input on this, and maybe help out some aspiring artists as well. So anyway, how do you set up your Blender interface?
Just for fun, did you know that MMB click and drag can move your window headers back and forth as well as the panels in the buttons window?
Well here is mine:
http://uploader.polorix.net//files/549/Rename%20this%20to%20.B.blend.blend
I use the Dark Rounded theme (a little modified for more consistency and ease of use. Then I have a whole bunch of screens for various uses:
Modeling (Just Default, but some tweaks)
Modeling (4 Screen like many other programs)
Animating
Materialing/Texturing
Materialing (Nodes)
Organizing
Compositing
Sequencing
Scripting.