Yes, Cross frame denoising will help alot, but it may not solve all flickering or dirt pixels problems.
I have forgotten to add some missing information about the plugin.
Rendering output can be set as one of the following:
a) “AVI_RAW” (this is preferred option),
b) “FFmpeg video” - AVI container with codec H.264 and lossless quality (I haven’t tried to use other quality options),
c) PNG (all frames will be connected to AVI file and then it will be processed as input for denoising, but require an FFMPEG installed),
so you can make an animation using PNG as output and afterward you can click generate the script with will convert all PNG’s to the movie which will be processed as an input for script :), but of corse, it won’t change your PNG’s.