Does frequent rendering with Blender Fry your computer?

If you render 250 frames straight in one day for a few days, will it fry your computer and destroy it faster?

by the way, my GPU is pnly GTX 1060, CPU i5.

Does your software normally wear out your computer?

No.

That depends. How is your cooling? =)
While, no, software will not normally wear out yur computer, heavy thermal stress can and will shorten CPU or GPU service lives, IF there is not sufficient cooling capacity. Watch your CPU/GPU temps. If they are going above rated service specs, yes, you have a problem. If they are staying within specs, then don’t worry about it, you’re fine! =) Happy Blending, and may the Source be with you…

Since this is patently a RENDERING question, why is it in the Modeling category?

https://blenderartists.org/c/support/lighting-and-rendering/48

And most devices these days will slow down due to high temperatures rather than overheat.

If you over volt your CPU/GPU that is most likely to shorten the lifespan through the higher wear on transistors (directly) as well as higher temperatures (indirectly)