Does Size Matter?

I’m wondering whether it matters if all of my objects are scaled to fit into the default grid of the 3D window? Could having objects outside this area cause any problems, like slowing down the animation or render systems, or cause BlenderPublisher to close when trying to open the NLA window in such a file?

no I dont think so…

there is a limit of 1000 grids, I think.

If you change the 3d window to a buttons window, you can adjust the number of gridlines.