Although it isn’t free or open source Pixel is a dream come true! I will be buying this monday. I have been using it for the past 2 hours and I am hooked. Photoshop is bulky and Gimp just doesn’t cut it. This however seems to fit the bill nicely! Only £20!
If you are looking for a photoshop alternative, look no further. Why can’t GIMP take a hint and make it like we want it?
Pixel, I love it
Also there is Opencanvas, and Dogwaffle, but dogwaffle has a crazy interface