Hi,
I tested my fluid simulation skills,
and evrytime I bake then the domain disappears,
The animation is OK then but I can’t
edit anymore,because the domain is gone :S
How to find it back
The domain is the fluid blob. Select that and the domain options should pop back up into the Animation.Effects window. Just change settings and bake again.
you can confirm this by checking the object name or by hitting tab to go into edit mode.
It would probably be nice if there were an option to “clear bake” as there is for soft bodies but I did not see that.
If you accidentally cancel the bake before any frames are done, or bake an empty domain, use Ctrl>Shift>F9 and click the name of your domain.
Ok Ty guys 
A couple more suggestions you could try here:
http://blenderartists.org/forum/showpost.php?p=868729&postcount=2
What I do is press TAB so that it shows it as a cube, then turn off fluid sim for the domain, press TAB again and turn the fluid sim back on. Seems like a long way around, but over time you get used to the sequence. I do this because sometimes when it bakes, no fluid turns up (eg, if you have your resolution too low), and so it’s impossible to right click on the domain.