Full Screen Advice?

I have never done a game that takes up the whole monitor. What is he best way to do it? Should I restrict
the resolution? Or just click full screen? Etc. . .


Depends on your needs. If you are just doing this for your own sake, then set the resolution to something that works for your computer and leave it alone. If you want to distribute it then you want to provide people with the option to control the resolution so it works with their computer.