qutorial, nice to meet you gives hand
hand.blend (416 KB)
hahaha just kidding, but this was my first hand.
About the topology - whatever works. Try animating it and see if everything is alright. Or try hi quality renderings if it’s a still. As much as I figured, best way to do this is simply sculpt whatever you need without worrying about any topology, just concern yourself with the shape.
When you sculpt the hi poly model, simply extrude faces of low poly cage with surface snapping over it. That way you need not worry about the form, only about topology. Plus it’s more comfortable to work like that. I used to model from scratch like this some time ago, but its way harder.
If you are unable to build dyntopo for Blender, try Sculptris, which is free, too. Then export mesh to blender and do the retopo.
But strangely enough, I’ve found that tentacles, fingers and such are easier done by extruding polygons.
BTW, don’t look my hand - it’s bad it was just for a handshake purposes and yours looks much betters!