How do I resolve keyboard conflict OSX

I am using blender on OSX and a lot of the shortcuts I saw in the manual aren’t working. When I was using the knife tool pressing E instead of being able to create a new cut it did nothing.
When I try to select shortest path with either cmd clicking or ctrl clicking it does nothing.
When I try this on a PC it works. Is there a way to Make this work on OSX?
I tried to unassign the cmd and ctrl key in the preferences, but it did nothing.
Switching to PC is not an option at the moment.