How to access values within a 2nd, closed .blend-file?

I am working in a .blend. Can I access (through Python) a 2nd, closed .blend-file?
I would like to access values like object-positions (I know the names of the objects).

You will have to open the file, one way or another. I assume you don’t want to manually decode the whole blend file into python just to get to the values.

You could use the the linking API:

So link an obj (you can link only the ones with the names you want) from your other file into the current file, and then get the location from that.

I often will link in a whole scene if I need to reference a lot of external objects