what your looking for is fairly advanced stuff, well, not advanced exactly but complicated. you need to plan your shot from the beginning, how do you want the effect to proceed and what is the end result, will you map your actors face to an object and then have the 3D mask reveal some face melted practical make up, or will you use multiple layers of 3D masks? then make sure you have tracking markers on the face of your actor, just small dots in key locations of the face, then, you can track the shot but you’ll need to familiarise your self with the tracking tool which is a fairly extensive tool kit. you’ll also need to know how to make the mask, which really is as simple as plotting a mesh face around your actor, but then you need to texture it to look seamless against your actor, not a big deal unless your actor is writhing around in agony, then you’ll need to make sure the texture works in all frames.
then there’s the animating, again a simple thing, but time consuming and there are several ways to achieve this most likely using shape keys ,but you could also use dynamic paint or even do weird things with displacement textures.
then there’s the compositor to put every thing together…
it sounds like a fun project and i hope you tackle it. but just don’t expect it to be a quick job!