Hybrid - Animating 2D Facial Expressions on a 3D Character

I’m also posting this in the “Animation and Rigging” forum as since it covers both areas.

I’m trying to animate simple 2D facial expressions - cartoon style on a 3D character.
In other words, I’m not modeling the mouth, eyes, etc. I’m simplifying the facial expressions down to a 2D facial expression and want to animate the 3D character with them.

I’m sure there are many ways to accomplish this, but if anyone has an efficient workflow to animate it as a texture (need to be able to swap out different expressions during the animation - of course) I would greatly appreciate if you could share it.