Infuriating startup issue

My sincere apologies for creating a problem thread as my first post, but I am at the end of my rope, and I do intend to be a future contributor to these forums.

I am running Blender on a Macbook Pro with Leopard. My problem is that whenever I start the program up, it opens with a particular project with all windows and preferences exactly the same (i.e. not at all how I want it). The weirdest thing is that I’ve deleted the .blend file that opens, which somehow still shows up! I can get it back to how it should be, which is a new, blank project, on startup by doing File > Load Factory Settings, but honestly I don’t like unnecessary workarounds.

Here’s what I’ve done to try to resolve the problem:

Deleted blender folder, downloaded again, put in applications folder (several times)
Deleted said .blend file (as mentioned)
Deleted all files in /tmp/
Searched for any files deep in system (ex. .plist in Library/Preferences/, which doesn’t seem to exist for Blender), but there could certainly be things that I’m unaware of

I’m not sure if there’s any correlation, but the problem began occurring either when I installed or when I uninstalled Lux Render.

This has been simply maddening, and I’m really hoping that I’m overlooking something boneheaded, because it seems to defy all logic.

Thanks in advance for your help.

You must have hit CTRL+U at some point. This makes the current set up the default one.

To fix it you can either find and remove .B.blend or go to File -> Load Factory Settings.

Thanks so much. I just loaded factory settings and hit ctrl-U again :confused: