I am working with Blender 2.59 on a windows 7 machine using an i7 processor. Evertime I try to reopen a previously saved scene, blender does not load with my saved default settings and i have to re-import my key config script to get it to work properly again.
If anyone knows a workaround or a fix please let me know.
When you open a blend make sure you have unticked ‘Load UI’ in the blender file browser. You can set this to be off as default in the user preferences.