Making a setting Default?

Some adjustments in Blender are really, really tedious, things you always use like:

in Editing (Texture Face): Two Side, Clip Alpha (otherwise the alpha channel looks terrible + you’ll only see one side. Maybe it’s preferable in some rare situations, but i cant think of any)

I import / export to numerous different folders, is it possible to have those selectable somewhere or set as defaults?

I’m using 2.49b.

Thanks.

I don’t know, but if anyone finds an answer for this question in 2.5 can they let me know? This would be really useful.