Migraine therapy: Monoclonal antibodies block the calcitonin geen related receptor (CGRP)


The calcitonin gene related peptide (yellow) binds to its receptor (blue) on neurons and smooth muscle cells of cerebral blood vessels, activating a signal cascade through G-proteins (dark blue) in this cells, that leads to a dilatation of the blood vessels (vasodilatation). Blocking the CGRP receptor diminishes the quantity of migraine attacks.