Welcome to BlenderArtists Brows3!
I don’t believe there is any way to change the cursor, but you can change the color of the grey background.
To do this, pull down the top header to show the User Preferences window. Go to the “Themes” tab. Hit “Add”. This will make a copy of the “Default” theme. Under the first drop down menu, select "3D View. Under the second menu select “Background”. Change the color to something that is good for your eyes. If you like the color and want to keep it, you will have to hit CTRL+UKEY which will save your defaults. But watch out, when you hit CTRL+UKEY, everything you see, will show up the same when you open up blender, so push the user preffs window back up before hitting CTRL+UKEY.
I hope that wasn’t too confusing and I hope it helps.