Multimonitor setup

Is there a good UI layout for multimonitor use?

Running 3 HP LA2405wg’s side by side (with one GPU) and would like to reserve one for the 3D viewport and move the rest of the UI to the ones on the sides.

Well you can configure the UI however you want. Under Window you can add a new window and move it to the other monitor. You can rescale and merge the tabs however you want and you could even add a new workspace.

Ok, but doesn’t open to the same layout the next time.

Go to File > Defaults > Save Startup File.