Man I feel your pain.
If your hands are bigger than mine then you are screwed.
Apparently the majority of the world is small with tiny hands. I’ve tried just about every mouse I could get my hands on and only a few of them are more then two-fingers wide.
The best option by far is a (wacom)tablet, I can work hours on end without pain or cramps.
If that’s not up your alley then I’d suggest the Logitech G5/7. I’m not a “gamer” but the adjustable resolution of the mouse via buttons on the back is just as useful in Blender.
Since they are heavier (G5 is completely adjustable through weights) and have a nice grip-material they are surprisingly comfortable to use despite still being too small for me. That said they are bigger than the Microsoft mice I tried and way more comfortable.
Why don’t they just make stuff in larger sizes? I don’t consider myself to be very big, but even I have major problems with finding the right size cars, furniture, etcetera. How people can operate those minuscule buttons on mobile phones is beyond me. You’d expect things to be better over here in Holland. Supposedly we’ re the tallest people in the world, so how come there’s nothing my size then?
Sorry for the rant, but if you’re confronted with this problem several times a day it really gets on your nerves.