Not exactly a modelling issue, but maybe close enough

Blender can do a lot you’d think it couldn’t, and sometimes can’t do things you’d think it could so I’m not sure if blender can or can’t do this, which is why I’m asking:

Can blender calculate the volume of a closed mesh, especially one of irregular size?

Yes, addons have volume calculation
http://wiki.blender.org/index.php/Extensions:2.6/Py/Scripts/Mesh/VolumeTools
http://wiki.blender.org/index.php/Extensions:2.6/Py/Scripts/3D_interaction/Panel_Measure

thanks.
thanks.