Objects moving out of alignment after render or reopening file

I have created a scene that has 3 objects that I have aligned together. If I render the scene or save it and reopen it the objects have jumped from their original location. Is there a fix this?
[Edit] I am using Blender 2.61

You probably have a keyframe set somewhere. Delete the old keyframes in the dope sheet and then move your objects. If you now set a keyframe, and you move them by accident, they’ll snap to their new locations so you won’t accidentally mess up your positioning.

Thanks Spire, that was it. I must have accidently created a keyframe. I haven’t ever looked into using those yet, I assuming it has to do with animations.