Performance issues with high poly editing

Ah, OK, I thought you wanted to sculpt your concept without Dyntopo lag, but you were talking about an already retopologized mesh. In that case I’d check out Quad Remesher, as @norka suggested. You won’t keep your UV coordinates though, in case you already added those.

Do note that Multires sculpting has issues in its current shape. It needs to be looked at.