When I want to save my render as a PNG it automatically sets to color depth to RGB.
Is there a way to set RGBA as the default?
Open a fresh Blender. Go to the Output Properties. Set your favourite output format (like PNG / RGBA in your case) and then use File > Defaults > Save Startup File.
Next time Blender will offer you this format first.
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Exactly. Everything you set in the startup file will be your “default”. Like e.g. 24fps or the render resolution.
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Got it, thanks!