Space navigator did not work on my desktop PC with Blender, but it did on my notebook, although I used same drivers, same NDOF-blender version, same plugin etc.
The difference was that I had not installed the Microsoft Visual C++ Redist.
After downloading the file “vcredist.exe”(2.6MB) from Microsoft homepage ( http://www.microsoft.com/downloads/details.aspx?FamilyID=32bc1bee-a3f9-4c13-9c99-220b62a191ee&displaylang=de
)
and after installing, my space navigator works now perfectly with Blender!!!
Maybe you just need to adopt the button and axis specifications for your personal feeling, but that is all.
Hope that helps!