Shape Keys later destroy the mesh

I keep having the same problem with all my shape keys. After awhile all my shape keys when activated will destroy my mesh. It never happens at first. Seems to always happen when I close out blender and come back the next day. What would be causing this to happen? Never had this problem with shape keys before.

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To add, I did move around some verts. But I went to all the shape keys after to make sure they worked and they were fine. It’s only ever LATER they go all crazy.

Are you changing the topology or adding/removing verts after making the shapekeys? They rely on each vertex being numbered the same as it was when the shapekey is initially created, or else it’ll go nutso.