Kay, mine is much simpler,
I have a custom event handler that allows me to just use a tablet pc (OR STANDARD WACOM) for input and use no key shortcuts at all (well almost). I usually just work in the one window, sometimes I’ll add an outliner and spolit the main view into two, the view on the right I change to whatever i need, uvimage editor, node window, whatever. this gives me 3-4 windows max…
I customise to the task directly, so my default is pretty simple really wheras any individual blend can be much more complex depending on the task at hand.