I’ve been working on simulating a hand-drawn look inside of blender. Here’s a link to the animation. http://www.vimeo.com/6752393
And here is an explanation: http://trevorjlee.com/2009/09/25/simulating-hand-drawn-animation-in-3d/
I’m pretty happy with the results, although I have not solved the problem of how to handle characters turning.
Love to hear your thoughts.