Unable to save user defaults

http://img541.imageshack.us/img541/7366/blenderwhut.png
what?

Any of these help ?
http://www.blender.org/forum/viewtopic.php?t=14860&view=previous&sid=ad74df1e233308dc37a89fbcf5c41d4d
http://blenderartists.org/forum/showthread.php?t=146659&pagenumber=
http://blenderartists.org/forum/showthread.php?t=152969&pagenumber=
Search for the .b.blend file that holds the user preferences and delete it (it can be in various places depending how you installed blender).
Try using the zip file instead of the installer.
Use File / Load Factory settings and then try saving your new preferences.

Thanks, guy!
Running as administrator worked.