You can render out from a (source) scene if you need a specific re-render. The VSE uses the render range defined by it’s start / end frames of the timeline. You can of course change that and render from the VSE but you won’t have a good filename convention.
Remember that renders take the output file name you define, so you could end up with a bunch of renders with the same header just different frame counts. That’s ok, unless you move the location of the strip later.
Proxies are low res versions of your scene strips. They playback smoothly on any machine, where as your high res frames may not.
What I have missed out here is:
- Audio handling between source scene and master (you can have sound in the source scene to animate too).
- High res pre-rendering of shots (you can create meta strips in the VSE nd swap between the OpenGL version and the high res master frames).
Also people do suggest that you render frame sequences from Blender for quality sake. The combine your sound and vision elsewhere (muxing). This is because Blenders built in movie renderer can be difficult to get good results from (ffmpeg implementation issues).