In a final render would you choose 1080p with denoise and 1000spp or would you choose 2160p with 300spp +denoise?
If i was going to downscale the final image back to 1080p.
Is more spatial resolution better, that more samples?
Lower resolution with more samples. Samples not only means dot per pixel, samples determine your shader result quality.
Whichever suits your situation best.
Whichever is quickest to render, if that gives you want you want and need, is there a reason to take the more time-consuming option?
Depends. But if I can get away with the lower sample count without introducing horrible denoise artifacts, I tend to render higher res low sample and downsample with sharpness. It helps prevent denoise from removing details which could otherwise be lost.
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