…new (ctrl + x)??? I just lost half an hour’s worth of work because I accidentally hit ctrl+x instead of x! (and ‘no undo available’ further enraged me!)
Is there ANY way to disable that idiotic hotkey??? It may not show up in text form, but writing this clean of a post is taking considerable restraint on my part.
I personally love that hotkey… but opinions aside, the short answer to your question is “not yet… at least not without compiling your own custom version of Blender”
First time I’ve seen that particular complaint. Usually it’s the no confirm on quit. Supposedly when 2.5 comes out, the hotkeys will be customizable. I suspect many people will use that facility to remove some of these hot keys, although the impetus behind it seems to be the capability of making the hotkeys match other 3D packages, so a person using both won’t have to code switch (that’s a linguistic term, not a programming term) when switching software.
I’d be just as happy leaving the destructive non-undoable options on the menu only, but I’m not in charge. Be patient, LazyCoder, keep breathing. 2.5 is coming. Real soon now. Really. 
ohh, have I done that before…
Though generally, when I do something stupid I kick myself; after all, the software only did what I told it to…
It is so you don’t have to quit and then reopen.
Hm… The worst thing is switching layers when you haven’t yet learned about layers… Everything is just gone, but Blender is still happy. Its not even like blender restarted, because the default cube isn’t there! I actually restarted my entire project two or three times (in the first few weeks of learning blender) because of this. Not saying that anything about layers should be changed… but…
doesnt it ask you if you want to “Erase All”? the full reason the prompt is there is to avoid this… you really need to realize what key(s) you just hit before you dismiss that prompt. And be sure you know HOW to accept a prompt and how to dismiss it. I once worked on a project, I saved often, but I kept overwriting the original files but whenit asked me if I wanted to save over, I just shook my mouse. then I exited blender, opened my file, and… nothin’
Now, however, I save in versions. Undo can only go so far…
And recently I learned of Autosave 
Yea but the problem is is when you’re used to is asking you when you just want to delete an object. I got out of the habit of reading that, and I was also going through different objects, deleting quite quickly.
I’ve just never had to completely wipe out my entire scene with that kind of urgency that would require a hotkey.