Just went to add a new layer to a GP object only to find the buttons are greyed out in the dopesheet:
The equivalent functions are working as usual over in the properties panel, and working if I open a new project and add a GP object. Not if I make a new scene in this current project and ad a new GP object though…
I believe this is because you need to have Only Show Selected enabled and a Grease Pencil object selected. Only Show Selected requirement isn’t intuitive or clear as to why.
You are in Dopesheet mode.
Dopesheet have to be in Grease Pencil mode to see buttons.
And @drpontchartrain is right. Only Show Selected button has to be enabled.
Those buttons can only be used by active object.
You are adding/removing a layer on one specific GP object, not all animated objects.
So, the filter is emphasizing this idea.
Although you can have several Grease Pencil objects selected, +/- buttons will only manage layers of active one.