From my quick inspection, it appears that your topology is OK. There are a few rough spots that could use some smoothing to get a more uniform quad surface, but for a hard surface model, as long as its not causing surface artifacts and the extra loops are needed elsewhere for structure, id say its fine. Perhaps someone thats more of a topology hardliner could chime in, I’m more practical on the topic! Haha
What was your intended use for this model? After I inspected it a bit more I found a few more mechanical issues that would be show stoppers if you intended to animated it. Puush is being dumb right now so i’ll just explain in text. The hammer is not fully modeled, which would make animating it awkward to say the least, and along the same line, the trigger is fused with the frame.
(not my image, borrowed from apexgunparts.com
for reference/educational fair use)
Not a colt python, but the overall structure is similar enough that only a hardcore enthusiast would say anything, as long as the externally visible form is consistent with the actual gun, and the working parts are “somewhat” close to its intended function. On the diagram, 09 and 43 are the hammer and trigger respectively, notice how they pivot and all the structure that’s hidden within the frame of the revolver. Parts of this would become visible in an animation so parts like these should be fully modeled.
Edit:: Also, your barrel is not rifled. This is a bit important, since many animations using guns involve following the bullet down the barrel in creative ways, lack of rifling would stand out. This one might be tough to fix without wrecking the topology. Making a negative object to subtract with boolean would be the fastest “cludge” fix, it will more than likely butcher the surrounding topology. Best thing i can think of is to delete the vertices of the inside of the barrel, and create a circle primitive with the rifling groves extruded around it. then extrude that to the length of the barrel, subdivide the funky tube, and twist it. Then have a wonderful time trying to weld it in to the external parts of the barrel. lol