Characters modeled in Blender, textures made in Gimp and background designed in Krita.
The characters are modeled in 3D, use shader cartoon and the outline tool. I added some details with Grease Pencil. The drawing style of the cowboy was inspired by Moebius and other authors on comics from the 70s.
Here is the “Behind the Scenes” article for this brilliant artwork!
Do check out this article, written by the artist himself. It describes the step-by-step process of creating the artwork and provides insight into scene-designing in Blender.