Will I be able to use GPU rendering, will the program run smoothly, etc.
You should see no significant difference
Thank you 
on win 10 no problems up to now
only thing is with the forum here
when I make some PM if you touch some keys you loose the page !
sorry don’t know about big GPU card
well there is one bug in folders for win 10 and bl files
if you save a blend file
you may have to change folder then come back or you are not able to click on the old bl file !
happy cl
I just posted a thread on this. I can’t get blender to run at all in Windows 10. I just get a blank DOS window with a blinking cursor and that’s it. I tried 2.74 and then 2.75a and no luck.
re check if your win 10 is good and complete
I installed win 10 last week and mostly much better then the old win 8.1
no problems in general with blender at all
happy bl
just found a bug on forum here
on win 10 edge
I cannot get to the forum site contact on top header somehow
happy bl
Over all Win 10 is great, Photoshop, LightWave, 3D-Coat, and games have no problems. blender is the only app I’ve had a problem with.
well I did not have any problems with any App or programs I had
may be try to re install blender !
happy bl