Is it helpful to enable "Above 4G decoding" setting in the BIOS?

My GPU has 6GB of memory, and my system has 32GB of memory. There probably isn’t any other single programme that uses more than 4GB of VRAM on my computer other than Blender. I read about that “Above 4G decoding” thing, but I do not exactly understand it. Do you think it would be helpful to enable it for Blender?