I first tried 2.49, back than I was working in game development and a colleague started using it more and more often. Left click select, navigation in general and UI threw me off, felt like it’d be more intuitive if I was left handed. Gave it a try with 2.5 and maya viewport presets but since I was using maya on a daily basis I didn’t see a good reason to switch. Tried it once-twice a year since then, but only really sticking with it for the last 6 months or so. I am using it however on a daily basis in vfx production since then.
Started in 2004 with 3ds max as a freelancer, started working in production in 2005 using maya (had to use xsi and 3dcoat for a while as well), but it was mostly maya and zbrush for me, substance painter on and off when freelancing on the side. Swapped maya for blender in 80% of the cases now, vfx pipelines being built around maya there are situations I do have to use it, but it’s mostly for publishing my work though.
It’d be unfair to request features like zbrush or substance have - obviously it’d be nice to get a couple of them and I think it’ll get there over time. My work being quite specific I mostly miss a good system for shape keys, I’m doing facial shapes most of my time and doing inbetween or corrective shapes is quite convoluted at the moment.