Absolutely! Making a UV will help in all the texturing processes.
A texture mask is from the UV, and it is nothing more than a B/W greyscale image the Black being the Mask and the White being the new texture, the greyscale part of it blends the underlying texture with the new.
For Example…in your project doing the lips…1st you would need the UV… which is going to give you areas that you can mask…2nd …create the Mask…Using texture paint you would paint directly on the mesh a greyscale w>b on the lips the rest of the face would be black…
Lip Mask
You could then create a texture using just the Bump map+Normal Map and use the Mask to control the area of painting…and Texture paint using Stencil over the lips…
Take a look at this thread…even though it refers to texturing the same idea can be applied in sculpting by importing your newly made mask…