Rendering issue: Is there a good common preset setup render for 2d animations?

Hello, I didnt find a post about this, but, is there any kind of “best render setup ever”?

I have made a 2D animation about natural sucessions. But I did not match a good video output setup. Im using a H.264 extension with quicktime format and H.264 codec. And the videos are coming with a kind of flicking.

I usually export my anims in png sequences. But Im trying to render as videos latelly.

Here is the scene:

Thanks for replying…