I’m not sure if this is the correct place to post this, but the forum has changed slightly since I was a regular. Anyway, I was party to a discussion about how great it would be to use Blender like substance. Well, you can. It’s just kind of a pain to set up, but it could be simplified via python. The basic idea is that each “substance brush” would be a material assigned to your mesh, and you simply paint in the influences using v color or an image texture. Here’s a thread about the process: Can't Follow my own Instructions If someone would write such a script assuming it doesn’t exist already, you could be legendary. I have no mind for Python, sadly, or I would do it.
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There are a lot of add-ons that do this:
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PBR Brush…Add to Cart!
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Also worth exploring
plenty of tuts on youtube
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