Yes to both.
For the first one, all you really need to do is go into your scene settings on the right hand side, and select what measurement units you want to use.
I have mine set to Metric and mm because that’s what I use where I live. For Inches, you just switch to Imperial I think, and then change the length option to Inches. You also want to make sure it’s the Dimensions that you change and not the scale Scale should always be 1.
A circle mirror is a pretty simple shape. All you’d need to do is add a circle to your scene with a diameter of 6 inches, and then model around that shape. The precision would come from your printer. So you’d need to see what your printers tolerances are like. My printer, for example, has a tolerance of around .5mm. So if I have a hole for a 3mm screw for example, I’d make the hole 3.5mm. That’s the same in Blender or CAD. Things like Subsurf though, can affect the measurements, so be careful. If I’m using subsurf, and an item has a hole, I’ll generally add another circle snapped to my hole, with a higher poly count (32 verts perhaps) set to the size I want. That way, if my hole with subsurf shrinks a little, I can’ scale it back outwards until it lines up with my untouched, accurately dimensioned circle. Make sense?
It obviously depends on the design of the mirror frame you’re going for. But in CAD, it can be done in about 30 seconds. In Blender, it’s not going to be drastically different, though the tool-set is quite different.
A bobble head would work in much the same way. I’d just start by adding a cube, and making it the rough height, width and depth of your bobble head design. I’d then then just model next to that cube, and use it as a rough scale reference.
It’s also about preference, and the tools you best know how to utilise. Myself, I’d absolutely use a CAD program like Fusion360 for a simple mirror frame. It’s super quick, and making things to exact measurements is slightly easier I’d say. For a bobble head, I’d model it in Blender. Perhaps the bobble mechanism could be a separate piece done in CAD, but it’s just a spring on a piece of plastic, right? Not overly difficult to model.
But as I say…the most important thing is actually the printer itself, and how well it prints. I know my printers well enough now, that I can make tolerances between fitting parts by eye, especially if working in Blender.