Yeah something looks out of whack there… to get a smile I’d normally move Mouth Corner 1 up diagonally, Lip Lower down and Cheek up slightly. Your reference looks like it has a bit of Jaw down as well, and not much in the way of Cheek up. You’ll need to do some reshaping for the more personalised characteristics like thinner, more raised upper lip.
If you’ve sculpted or changed the proportions around the lips and the eyes, bear in mind you’ll likely also need to iron out any kinks that’s created in the shape keys.